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Protein Biochemistry
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U-18666A
U-18666A from Cayman Chemical
Be the first to write a review!
Citations:
(10)
Supplier Page
Supplier Page from
Cayman Chemical for
U-18666A
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Description
A cell permeable drug that inhibits cholesterol trafficking from late endosomes/lysosomes to the ER, but not to the plasma membrane
Product Specs
Company Info
Citations
Reviews
Product Specs
Item
U-18666A
Company
Cayman Chemical
Price
Pricing Info
Supplier Page
View Company Product Page
Catalog Number
10009085
Quantity
50 mg
Research Area
Cardiovascular System, Lipid Biochemistry, Lipid Transport, Lipids & Lipoproteins, Neuroscience, Sterol Lipids, Storage & Transport
Format
A crystalline solid
Molecular Weight
424.1
Purity
≥95%
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Cayman Chemical
Cayman Chemical Company 1180 East Ellsworth Road
Ann Arbor
,
Michigan
48108
United States
Phone
: (800) 364-9897
(734) 971-3640
Company Profile
Website:
http://www.caymanchem.com/
Citations (10)
(1)
SREBP activation contributes to fatty acid accumulations in necroptosis†
RSC Chemical Biology
April 5, 2023
Daniel Lu, Laura R. Parisi, Omer Gokcumen, G. Ekin Atilla-Gokcumen
#210-TA/CF). Atorvastatin (Cat #
10493
).
BIBB 515
(Cat #
10010517
), Ro48-8071 (Cat #
10006415
), U18666A (Cat #
10009085
),
Betulin
(Cat #
11041
), necrosulfonamide (Cat #
20844
) and
filipin III
(Cat #
70440
) were obtained
(2)
Cholesterol content regulates silica-induced lysosomal membrane permeability
Frontiers in Toxicology
February 13, 2023
Matthew J. Sydor, Rebekah L. Kendall, Andrij Holian
measurements was
Di-4-ANEPPDHQ
, which was purchased from
ThermoFisher
(Waltham, MA). U18666a (Item No.
10009085
) was obtained from
Cayman Chemical
(Ann Arbor, MI). The fluorescent substrate for n-acetyl-β-glucosaminidase
(3)
Cellular cholesterol licenses Legionella pneumophila intracellular replication in macrophages
Microbial Cell
January 2, 2023
Edna Ondari, Ashley Wilkins, Brian Latimer, Ana-Maria Dragoi, Stanimir S. Ivanov
described [79]. Reagents The following reagents were purchased from
Cayman
Chemicals -
u18666A
(cat #
10009085
), ketoconazole (cat #
15212
),
Filipin III
(cat #
70440
), NileRed (cat #
30787
).
Gemcitabine
(cat #
G6423
)
(4)
Sterol dysregulation in Smith-Lemli-Opitz syndrome causes astrocyte immune reactivity through microglia crosstalk
Disease models & mechanisms
December 1, 2022
Freel BA, Kelvington BA, Sengupta S, Mukherjee M, Francis KR.
(5 µM; DHCR7
inhibitor
;
Cayman Chemical
,
14611
), U18666A (20 nM; DHCR24
inhibitor
;
Cayman Chemical
,
10009085
) and atorvastatin (2.5 µM; HMG-CoA reductase
inhibitor
;
Cayman Chemical
,
10493
). All comparisons for
(5)
Novel Insights Into Sterol Uptake and Intracellular Cholesterol Trafficking During Eimeria bovis Macromeront Formation
Frontiers in Cellular and Infection Microbiology
February 11, 2022
Liliana M. R. Silva, Zahady D. Velásquez, Sara López-Osorio, Carlos Hermosilla, Anja Taubert
Additionally, progesterone (25–75 µM;
Sigma-Aldrich
, P0130) and
U18666A
(7.5 µM;
Cayman Chemical Company
,
10009085
) were used, which are both known to block intracellular sterol transport and release from
endosomes
.
(6)
Sterols lower energetic barriers of membrane bending and fission necessary for efficient clathrin-mediated endocytosis
Cell Reports
November 16, 2021
Ruthellen H. Anderson, Kem A. Sochacki, Harika Vuppula, Brandon L. Scott, Elizabeth M. Bailey, Maycie M. Schultz, Jason G. Kerkvliet, Justin W. Taraska, Adam D. Hoppe, Kevin R. Francis
and recombinant proteins",, AY9944,
Cayman Chemical
,Item No.
14611
U-18666A
,
Cayman Chemical
,Item No.
10009085
Atorvastatin
,
Cayman Chemical
,Item No.
10493
Simvastatin
,
Cayman Chemical
,Item No.
10010344
methyl-β-cyclodextrin
(7)
Iron loading induces cholesterol synthesis and sensitizes endothelial cells to TNFα-mediated apoptosis
The Journal of biological chemistry
October 1, 2021
Fisher AL, Srole DN, Palaskas NJ, Meriwether D, Reddy ST, Ganz T, Nemeth E.
for 40 h. For cholesterol-depletion studies, HUVECs were treated with 1 μM U18666A (
Cayman
Chemicals #
10009085
), 0.3% HPCD (#H107), or 50 μM MCD for the indicated times. For
inflammation
studies, HUVECs were treated
(8)
Mevalonate Pathway-mediated ER Homeostasis Is Required for Haploid Stability in Human Somatic Cells
Cell Structure and Function
February 19, 2021
Kan Yaguchi, Kimino Sato, Koya Yoshizawa, Daisuke Mikami, Kohei Yuyama, Yasuyuki Igarashi, Gabor Banhegyi, Eva Margittai, Ryota Uehara
compounds Compounds were purchased from suppliers as follows: Pitavasta‐ tin (163-24861, Wako); U18666A (
10009085
,
Cayman
Chemi‐ cal);
Cholesterol
(SLBZ0657,
Sigma-Aldrich
);
FTI-277
(
S7465
,
Selleck
); GGTI-298 (S7466,
(9)
Inhibition of PIKfyve kinase prevents infection by Zaire ebolavirus and SARS-CoV-2
Proceedings of the National Academy of Sciences
August 25, 2020
Yuan-Lin Kang et al.
gift from N. Gray, Dana-Farber
Cancer
Institute and Harvard Medical School, Boston, MA (33),
U-18666A
(
10009085
) and
Filipin III
(
70440
) were from
Cayman Chemical
,
Bafilomycin A1
(
B1793
-2UG) was from
Sigma-Aldrich
,
(10)
Mitochondrial biogenesis is transcriptionally repressed in lysosomal lipid storage diseases
eLife
February 18, 2019
King Faisal Yambire, Lorena Fernandez-Mosquera, Robert Steinfeld, Christiane Mühle, Elina Ikonen, Ira Milosevic, Nuno Raimundo
(
Biotrend
,
BG0162
), 5 µM
Sew2871
(
Cayman
,
10006440
), 20 µM
U0126
(
Millipore
,
662005
), 10 µM
U18666A
(
Cayman
,
10009085
), 10 µM W146 (
Sigma-Aldrich
,
W1020
), 2 µM
FTY720
(
Selleckchem
,
S5002
) and 4 µM Staurosporine (Sigma-Aldrich,
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U-18666A from Cayman Chemical
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